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Understanding Myocardial Infarction: Causes, Diagnosis, and Symptoms

Cardiovascular
Mr. W.G. is a 53-year-old white man who began to experience chest discomfort while playing tennis with a friend. At first, he attributed his discomfort to the heat and had a large breakfast. Gradually, however, discomfort intensified to a crushing sensation in the sternal area and the pain seemed to spread upward into his neck and lower jaw. The nature of the pain did not seem to change with deep breathing. When Mr. G. complained of feeling nauseated and began rubbing his chest, his tennis partner was concerned that his friend was having a heart attack and called 911 on his cell phone. The patient was transported to the ED of the nearest hospital and arrived within 30 minutes of the onset of chest pain. En route to the hospital, the patient was placed on a nasal cannula and an IV D5W was started. Mr. G. received aspirin (325 mg PO) and 2 mg/IV morphine. He is allergic to meperidine (rash). His pain has eased slightly in the last 15 minutes but is still significant; was 9/10 in severity; now7/10. In the ED, chest pain was not relieved by 3 SL NTG tablets. He denies chills.
Case Study 2 Questions:

For patients at risk of developing coronary artery disease and patients diagnosed with acute myocardial infarction, describe the modifiable and non-modifiable risk factors.
What would you expect to see on Mr. W.G.’s EKG and which findings described in the case are compatible with the acute coronary event?
Having only the opportunity to choose one laboratory test to confirm the acute myocardial infarction, which would be the most specific laboratory test you would choose and why?
How do you explain that Mr. W.G’s temperature has increased after his Myocardial Infarction, when can that be observed, and for how long? Base your answer on the pathophysiology of the event.
Explain to Mr. W.G. why he was experiencing pain during his Myocardial Infarction. Elaborate and support your answer.

 

 

 

Sample Answer

 

Title: Understanding Myocardial Infarction: Causes, Diagnosis, and Symptoms

Introduction

Myocardial infarction, commonly known as a heart attack, is a serious medical condition that occurs when there is a blockage in the blood supply to the heart. This blockage leads to the death of heart muscle cells due to a lack of oxygen. In this case study, we explore the risk factors for developing coronary artery disease and acute myocardial infarction, as well as the diagnosis and symptoms experienced by Mr. W.G. during his heart attack.

Modifiable and Non-Modifiable Risk Factors

Coronary artery disease (CAD) is the leading cause of myocardial infarction. Various risk factors can be categorized as modifiable and non-modifiable.

Non-modifiable risk factors:

Age: Advancing age increases the risk of developing CAD and experiencing a heart attack. Mr. W.G., being 53 years old, falls into this higher-risk age group.
Gender: Men, especially those above the age of 45, are more prone to CAD compared to premenopausal women. However, women’s risk increases after menopause.

Modifiable risk factors:

Smoking: Cigarette smoking damages blood vessels, promotes plaque formation, and increases the risk of blood clots, making it a significant modifiable risk factor for CAD.
High blood pressure: Uncontrolled hypertension strains the heart, leading to the development of CAD over time.
High cholesterol levels: Elevated levels of LDL cholesterol contribute to the formation of plaque in the arteries, narrowing them and increasing the risk of a heart attack.
Diabetes: Poorly controlled diabetes can damage blood vessels and increase the risk of CAD.
Obesity and sedentary lifestyle: Excess weight and lack of physical activity contribute to various risk factors such as hypertension, diabetes, and high cholesterol levels.

Expected EKG Findings and Compatible Acute Coronary Event Symptoms

An electrocardiogram (EKG) is a crucial diagnostic tool used to evaluate heart function and detect abnormalities. In Mr. W.G.’s case, the following EKG findings would be expected during an acute coronary event:

ST-segment elevation: An ST-segment elevation indicates myocardial injury, suggesting an acute myocardial infarction.
T-wave inversion: T-wave inversion is another indicator of myocardial ischemia or injury.
Q waves: The presence of Q waves may indicate permanent damage to the heart muscle.

Mr. W.G.’s symptoms, including chest discomfort radiating to the neck and jaw, nausea, and significant pain even after receiving medication like nitroglycerin, are all compatible with an acute coronary event.

Most Specific Laboratory Test for Confirming Myocardial Infarction

Among various laboratory tests available for diagnosing myocardial infarction, the most specific one would be cardiac troponin levels. Troponin is a protein released into the bloodstream when there is damage to the heart muscle. Elevated levels of troponin indicate myocardial injury or infarction. This test is highly specific for detecting heart muscle damage and is considered the gold standard for diagnosing myocardial infarction.

Temperature Changes after Myocardial Infarction

The increase in Mr. W.G.’s body temperature after his myocardial infarction can be attributed to systemic inflammation caused by tissue damage. During a heart attack, damaged heart muscle cells release pro-inflammatory cytokines, triggering an immune response and resulting in an elevated body temperature. This fever can typically be observed within the first 24-48 hours after a heart attack and may persist for a few days as the body heals.

Explanation of Pain during Myocardial Infarction

Mr. W.G.’s pain during his myocardial infarction can be explained by two factors:

Ischemia: The blockage in his coronary artery leads to a reduced blood supply to the heart muscle. This lack of oxygen-rich blood causes ischemia, resulting in pain or discomfort in the chest area.

Irritation of Nerve Endings: The damaged heart muscle releases various chemicals, including bradykinin and histamine, which stimulate nerve endings surrounding the heart. This irritation triggers pain signals that are perceived as crushing or pressure-like sensations.

In conclusion, understanding the modifiable and non-modifiable risk factors for developing coronary artery disease and myocardial infarction is crucial for prevention and early intervention. Timely diagnosis through EKG findings, confirmatory laboratory tests like cardiac troponin levels, and effective management can significantly improve outcomes for patients like Mr. W.G.

 

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