Crohn’s Disease

Crohn’s disease is a chronic inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, from the mouth to the anus. It is characterized by inflammation, ulcers, and abscesses in the digestive tract.

The exact cause of Crohn’s disease is unknown, but it is thought to be a combination of genetic and environmental factors. There is no cure for Crohn’s disease, but it can be managed with medication, surgery, and lifestyle changes.

Symptoms of Crohn’s Disease
The symptoms of Crohn’s disease can vary from person to person and can range from mild to severe. Some common symptoms of Crohn’s disease include:

Abdominal pain
Diarrhea
Weight loss
Fever
Fatigue
Mouth sores
Anal fissures
Fistulas
Diagnosis of Crohn’s Disease
There is no single test that can definitively diagnose Crohn’s disease. Diagnosis is usually made based on a combination of symptoms, medical history, physical examination, and laboratory tests.

Some of the tests that may be used to diagnose Crohn’s disease include:

Complete blood count (CBC)
Blood chemistry tests
Stool tests
Upper endoscopy
Lower endoscopy
Capsule endoscopy
CT scan
MRI
Treatment of Crohn’s Disease
There is no cure for Crohn’s disease, but it can be managed with medication, surgery, and lifestyle changes.

Medication

The goal of medication is to reduce inflammation and control symptoms. The type of medication that is used will depend on the severity of the disease and the individual’s response to treatment.

Some of the medications that may be used to treat Crohn’s disease include:

Aminosalicylates
Corticosteroids
Immunosuppressants
Biologic therapy
Surgery

Surgery may be necessary to treat Crohn’s disease if medication is not effective or if there are complications such as a bowel obstruction or perforation.

The type of surgery that is performed will depend on the location and severity of the disease. Some of the surgical procedures that may be used to treat Crohn’s disease include:

Strictureplasty
Bowel resection
Ileostomy
Colostomy
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Lifestyle Changes
There are a number of lifestyle changes that can help to manage Crohn’s disease. These include:

Eating a healthy diet
Exercising regularly
Getting enough sleep
Managing stress
Quitting smoking
Complications of Crohn’s Disease
Crohn’s disease can lead to a number of complications, including:

Inflammatory bowel cancer
Bowel obstruction
Perforation
Fistulas
Abscesses
Malnutrition
Weight loss
Fatigue
Depression
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Crohn’s Disease

 

 

Choose one of the following diseases*:

Crohn’s Disease
Multiple Sclerosis
Myasthenia Gravis
Celiac Disease

Conduct research online in order to answer the following questions:

What are the cellular/molecular mechanisms that underlie this disease? (What are actual “abnormalities” or “deficiencies” causing the disease?)
How common is this disease? Are there any particular susceptibility groups? (Be sure to also consider any genetic and environmental susceptibilities)
What are the disease symptoms?
What mechanisms are responsible for these disease symptoms? (Note: this is different from answer to question 1.)
How is the diagnosis made? What particular clinical tests are used to make this diagnosis? This answer needs to be precise and specific. For example, “blood test” is not a sufficient answer. Your answer must indicate what cellular or molecular components are measured and how, and what particular parameters are used to make the disease diagnosis.
What is the prognosis for someone with this disease?
What are the treatment options? (Be sure to mention mechanisms of action of treatments and to consider novel treatments recently approved or in development.)

 

Crohn’s Disease

 

 

Choose one of the following diseases*:

Crohn’s Disease
Multiple Sclerosis
Myasthenia Gravis
Celiac Disease

Conduct research online in order to answer the following questions:

What are the cellular/molecular mechanisms that underlie this disease? (What are actual “abnormalities” or “deficiencies” causing the disease?)
How common is this disease? Are there any particular susceptibility groups? (Be sure to also consider any genetic and environmental susceptibilities)
What are the disease symptoms?
What mechanisms are responsible for these disease symptoms? (Note: this is different from answer to question 1.)
How is the diagnosis made? What particular clinical tests are used to make this diagnosis? This answer needs to be precise and specific. For example, “blood test” is not a sufficient answer. Your answer must indicate what cellular or molecular components are measured and how, and what particular parameters are used to make the disease diagnosis.
What is the prognosis for someone with this disease?
What are the treatment options? (Be sure to mention mechanisms of action of treatments and to consider novel treatments recently approved or in development.)