Compare and contrast the two forms of monogenic obesity: Congenital
Leptin Deficiency and Prader Willi Syndrome
This essay requires you to describe and discuss the etiology, mechanisms, pathophysiology
and clinical aspects of both disorders. The essay should provide some background context
to obesity (definition, demographics, epidemiology etc.) before the discussion of the two
disorders.
The essay should include the following elements of both disorders (suggested %
contribution of each component in brackets) but for each of these components, there
should be direct comparative discussion of the disorders in question:
· Epidemiology and Demographics (10%)
· Diagnostic testing (10%)
· Treatment and management (10%)
· Clinical course and prognosis (10%)
· Genetic mechanisms (30%