Advancements in Drug Discovery and Personalized Medicine through Human-Derived Stem Cell Organoids: A Comprehensive Review

Write a Cancer Review paper covering the recommended topic related to current cancer research.
Cancer Review Recommended Topic:
Drug discovery and personalized medicine via human-derived stem cell organoids Liu F, Huang J, Ning B, Liu Z, Chen S, Zhao W. Drug Discovery via Human-Derived Stem Cell Organoids. Front Pharmacol. 2016 Sep 22;7:334. Review. PubMed PMID: 27713700; PubMed Central PMCID: PMC5032635.

 

 

Understanding Mechanisms of EGFR-Targeted Therapy Resistance in Cancer: A Literature Review

Write a Cancer Review paper covering the recommended topic related to current cancer research.
Cancer Review Recommended Topic:
Mechanisms of EGFR-targeted therapy resistance
Chong CR, Jänne PA. The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med. 2013 Nov;19(11):1389-400. doi: 10.1038/nm.3388

 

Here are the specific guidelines:
 Write a literature review on the topic of interest
o Identify, interpret, summarize and synthesize the relevant literature
 Identify possible gaps in the knowledge
 Formulate a clear and focused research question that should fill gaps in existing knowledge
– Research question should not be too broad
– Research question should start with Why? How? What? How much? How long? How often?
– Research question should shape the problem into a testable hypothesis
– Research question should lead to an appropriate study design and methodology
– Many of the clinical and research questions can be formulated using the PICO principle:
https://guides.mclibrary.duke.edu/ebm/pico

 

Cancer Review: Role of Stomach Bacteria in the Development of Cancer – The Human Microbiome

 

Write a Cancer Review paper covering the recommended topic related to current cancer research.
Cancer Review Recommended Topic:
Role of stomach bacteria in the development of cancer – The Human Microbiome
Gao R, Gao Z, Huang L, Qin H. Gut microbiota and colorectal cancer. Eur J Clin Microbiol Infect Dis. 2017 Jan 7. doi: 10.1007/s10096-016-2881-8. Review. PubMed PMID: 28063002.

Leveraging Data in Healthcare Practice: A Scenario Analysis

In the modern era, there are few professions that do not to some extent rely on data. Stockbrokers rely on market data to advise clients on financial matters. Meteorologists rely on weather data to forecast weather conditions, while realtors rely on data to advise on the purchase and sale of property. In these and other cases, data not only helps solve problems, but adds to the practitioner’s and the discipline’s body of knowledge.
Of course, the nursing profession also relies heavily on data. The field of nursing informatics aims to make sure nurses have access to the appropriate date to solve healthcare problems, make decisions in the interest of patients, and add to knowledge.
In this Discussion, you will consider a scenario that would benefit from access to data and how such access could facilitate both problem-solving and knowledge formation.
• Reflect on the concepts of informatics and knowledge work as presented in the Resources.
• Consider a hypothetical scenario based on your own healthcare practice or organization that would require or benefit from the access/collection and application of data. Your scenario may involve a patient, staff, or management problem or gap.
Post a description of the focus of your scenario. Describe the data that could be used and how the data might be collected and accessed. What knowledge might be derived from that data? How would a nurse leader use clinical reasoning and judgment in the formation of knowledge from this experience?

Carbohydrates: Blood Glucose Homeostasis

Response to each question must:
• contain well-developed sentences, correct spelling, and proper grammar
• demonstrate your achievement of those objectives for the lesson in your response
• include data, facts, key terminology, specific examples, and direct quotations from the textbook, Lesson and other resources to support your main point.
• include appropriate citation and a resource list for all sources used.
FON241LL
Lesson 5 Lab
Carbohydrates:  Blood Glucose Homeostasis
1. Define glycemic response and the glycemic index.  Provide two examples in which using the glycemic index may provide health benefits and explain how these foods convey these benefits.  (15 pts)
2. Is selecting foods based on the glycemic index a scientifically valid method for preventing or treating disease?  Why or why not?  Provide three reasons for your response.  (15 pts)
3. Choose three carbohydrate-rich foods from the food records you entered in your dietary analysis and using Table 4.4 in your textbook, determine the glycemic index for those foods.   Considering the components in these foods, why do you think that they fall in the category that they do?  (20 pts)
4. Explain how blood glucose homeostasis is maintained in the body.  Be sure to include in your answer how the hormones involved regulate blood glucose levels under the following conditions:  after a meal; during the night when you’re asleep; when you’re under stress.
(15 pts)
5. Compare the two major types of diabetes and explain at least three ways in which they differ.  (15 pts)
6. Identify three chronic (long-term) complications that can occur with uncontrolled diabetes and explain how this disease causes these complications.  (20 pts)

House Sparrow (Passer domesticus)

 

You have selected your focal species in Urban Wildlife Species Selection discussion. In order to predict how urbanization will affect your species, you need to know something about the ecology and conservation status of your species. Time to do some background research!To answer the following questions, you will need to search for credible sources of information, using Google Scholar, , or other online resources such as iNaturalist or the Encyclopedia of Life. (You can find information in other ways, but these are helpful places to get started!) Make sure that you cite all sources of information in the text of your responses and include the full citations in a literature cited section. Assignment Requirements

Title your submission with the common and scientific name of your species.
Species ecology For each response, you should have an in-text citation (author, year) for the source of the information.
What habitat types is this species found in? Describe the key features of these habitats
Consider common abiotic factors, such as temperature, shade, urbanization, and/or water availability. How do these abiotic factors influence the survival and reproduction of this species?
What is its role in the ecosystem? What does it feed on? Does it require trees or shrubs? Does it compete with other species? Does it have predators?
Species range and status For each response, you should have an in-text citation (author, year) for the source of the information.
What is the global distribution (species range) of your species? Is it observed worldwide or only found on certain continents?
What is the native range of this species? Is it native or introduced to southern California?
What is the conservation status of this species?
If it is native to Southern California, is it a species of conservation concern? Why or why not?
If it is introduced, how/why was it introduced and what makes the species successful outside of its native habitat?
Phenology (timing of important events in the life cycle) for your species For each response, you should have an in-text citation (author, year) for the source of the information.
What time of year does it reproduce?
Does it live in California all year? Or is it migratory?
Does it have times of the year it is more activity?
What time of the day is the species typically active?
Does it undergo a seasonal hibernation or daily torpor?
Species Adaptations For each response, you should have an in-text citation (author, year) for the source of the information.
What behavioral, physical, or physiological characteristics does the species have that make it well-adapted for its environment?
Does this species adapt well to urbanization? What behavioral, physical, or physiological characteristics allow it to adapt well (or make it difficult to adapt)?
Hypotheses – Based on your background research state your hypothesis for the following:
When do you think your species will be most likely to be found in the camera trap data? (dawn, day, dusk, night, or deep night)
What other variable do you think might influence when your species is sighted on the camera traps? (temperature, nearby buildings, streets, water sources, % of tree canopy cover, shrub cover)
Explain your reasoning behind each of your hypotheses and use at least 1 source or each (it can be the same source).