Category: Biology

United States Equal Employment Opportunity Commission

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Go to the United States Equal Employment Opportunity Commission and review the section titled Prohibited Employment Policies/Practices
Provide examples of two of the following that you or someone you know has experienced or witnessed: unfair recruitment, employment application, and interview process. Investigate the extent to which the chosen technique or method left room for prohibited employment practices. Next, recommend key corrective actions that an organization could take to mitigate prohibited employment practices.

Cognitive dissonance.

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1. Explain what is meant by cognitive dissonance. Why is this concept important to marketers?

2. Give two examples of services that show a good match between customer expectations and service delivery. Give two examples of services that do not show a good match. Explain your rationale or criteria for your conclusions.

3. Artificial Intelligence is becoming a major disruptive force that will have both positive and negative effects on our economy and the workforce. Provide two positive and two negative examples that are consequences of the growth of AI. Explain your rationale or criteria for your conclusions.

 

Glycolysis, Warburg effect & Cancer: Role of thiols

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This week you learned about glycolysis and the chemical reactions and enzymes involved in this important metabolic pathway. You further learned that glyceraldehyde phosphate dehydrogenase (GAPDH) enzyme is not only an important key regulatory enzyme of glycolysis, but also recognized as a “moonshining” enzyme. GAPDH is also long known as an enzyme that is prone to inhibition by many toxins, e.g., Pertussis toxin, alkylating agents and many thiol compounds. You also heard about the Warburg effect in connection with glycolysis.

As you work on this week’s discussion board assignment, consider the following:

Cervical cancer is the second highest number of deaths in female cancers, exceeded only by breast cancer. This cancer carries high risks of morbidity and mortality amongst women.
Most cervical cancers cells show abnormally high glycolysis rates.
The current standard of care for locally advanced cervical cancer is concurrent cisplatin chemotherapy with pelvic irradiation.
Despite significant advances in radiation treatment delivery, more than 30% of patients fail this treatment.
This week:

Please read this scientific article: Rashmi R., Huang X. et al. Radio-resistant cervical cancers are sensitive to inhibition of glycolysis and redox metabolism. Cancer Res. 2018 March 15; 78(6): 1392–1403.
Do some research on NCBI Pubmed (www.ncbi.nlm.nih.gov/pubmed) on this week’s topic.
Then discuss the following aspects with your classmates:
What is the Warburg effect? How is it connected to glycolysis?
What are some of the reported metabolic characteristics of cervical cancer cells?
What do scientists consider important thiols which may be responsible for the resistance of cervical cancer cells to radio and brachytherapy?
Why and how do increased thiol levels confer increased resistance to radio- and brachytherapy? And how can thiol levels be manipulated?
Which glycolysis enzyme is the most likely target candidate for thiol therapy? Why?

 

Glycolysis, Warburg effect & Cancer: Role of thiols

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This week you learned about glycolysis and the chemical reactions and enzymes involved in this important metabolic pathway. You further learned that glyceraldehyde phosphate dehydrogenase (GAPDH) enzyme is not only an important key regulatory enzyme of glycolysis, but also recognized as a “moonshining” enzyme. GAPDH is also long known as an enzyme that is prone to inhibition by many toxins, e.g., Pertussis toxin, alkylating agents and many thiol compounds. You also heard about the Warburg effect in connection with glycolysis.

As you work on this week’s discussion board assignment, consider the following:

Cervical cancer is the second highest number of deaths in female cancers, exceeded only by breast cancer. This cancer carries high risks of morbidity and mortality amongst women.
Most cervical cancers cells show abnormally high glycolysis rates.
The current standard of care for locally advanced cervical cancer is concurrent cisplatin chemotherapy with pelvic irradiation.
Despite significant advances in radiation treatment delivery, more than 30% of patients fail this treatment.
This week:

Please read this scientific article: Rashmi R., Huang X. et al. Radio-resistant cervical cancers are sensitive to inhibition of glycolysis and redox metabolism. Cancer Res. 2018 March 15; 78(6): 1392–1403.
Do some research on NCBI Pubmed (www.ncbi.nlm.nih.gov/pubmed) on this week’s topic.
Then discuss the following aspects with your classmates:
What is the Warburg effect? How is it connected to glycolysis?
What are some of the reported metabolic characteristics of cervical cancer cells?
What do scientists consider important thiols which may be responsible for the resistance of cervical cancer cells to radio and brachytherapy?
Why and how do increased thiol levels confer increased resistance to radio- and brachytherapy? And how can thiol levels be manipulated?
Which glycolysis enzyme is the most likely target candidate for thiol therapy? Why?

 

Adolescent Brain

Posted on | by Brian Leakey
  1. Go to this website to learn about a huge and amazing research study currently following over 10,000 children!

First, watch this short video and write a one-paragraph summary about the “ABCD” study. Start by defining what “ABCD” stands for.
https://abcdstudy.org/about/ (1:41)

Second, go to the news page for the ABCD study at: https://abcdstudy.org/news/ to explore. Identify ONE study that the ABCD study has completed so far (there are LOTS). Explain what the researchers are studying and the results thus far! 😊

  1. Read the attached document on social media use and mental health. This is a summary of the research in this area—and parts of this read are a bit difficult. I encourage you to read and think through all sections (in order) but focus your time on the three sections in PURPLE. After reading and mulling over this information (and taking notes or highlighting as you read), write a 1-2 paragraph summary about the key points. There is A LOT that you could write for your summary but aim to focus on the most important and interesting information as you see it.
  2. Explain TWO textbook concepts that you find particularly important or interesting. Fully describe your concept/term/theory and provide a personal example to demonstrate your understanding of it! (one paragraph each)

Breast cancer.

Posted on | by Brian Leakey

Mrs. Williams is a 27-year-old female diagnosed with breast cancer. She is currently in pharmacy school. She does not have children but hopes to have them someday. She has been tested and has a genetic predisposition for this disease.
• What treatment options does she have?
• What are the advantages and disadvantages of those treatment options?
• What would you tell Mrs. Williams if she decided to refuse treatment?
• Mrs. Williams really wants to have children before she starts treatment. What would you educate her about? Why?

Glycolysis, Warburg effect & Cancer: Role of thiols?

Posted on | by Brian Leakey

This week you learned about glycolysis and the chemical reactions and enzymes involved in this important metabolic pathway. You further learned that glyceraldehyde phosphate dehydrogenase (GAPDH) enzyme is not only an important key regulatory enzyme of glycolysis, but also recognized as a “moonshining” enzyme. GAPDH is also long known as an enzyme that is prone to inhibition by many toxins, e.g., Pertussis toxin, alkylating agents and many thiol compounds. You also heard about the Warburg effect in connection with glycolysis.

As you work on this week’s discussion board assignment, consider the following:

Cervical cancer is the second highest number of deaths in female cancers, exceeded only by breast cancer. This cancer carries high risks of morbidity and mortality amongst women.
Most cervical cancers cells show abnormally high glycolysis rates.
The current standard of care for locally advanced cervical cancer is concurrent cisplatin chemotherapy with pelvic irradiation.
Despite significant advances in radiation treatment delivery, more than 30% of patients fail this treatment.
This week:

Please read this scientific article: Rashmi R., Huang X. et al. Radio-resistant cervical cancers are sensitive to inhibition of glycolysis and redox metabolism. Cancer Res. 2018 March 15; 78(6): 1392–1403.
Do some research on NCBI Pubmed (www.ncbi.nlm.nih.gov/pubmed) on this week’s topic.
Then discuss the following aspects with your classmates:
What is the Warburg effect? How is it connected to glycolysis?
What are some of the reported metabolic characteristics of cervical cancer cells?
What do scientists consider important thiols which may be responsible for the resistance of cervical cancer cells to radio and brachytherapy?
Why and how do increased thiol levels confer increased resistance to radio- and brachytherapy? And how can thiol levels be manipulated?
Which glycolysis enzyme is the most likely target candidate for thiol therapy? Why?