Anthracycline-induced cardiotoxicity and senescence in the heart

F​‌‍‍‍‌‍‍‌‍‌‌‍‍‍‌‍‌‌‌‍​ocus on the mechanism of doxorubicin upregulating the vascular adhesion molecules (VCAm-1 and E-selectin). I prefer to write a paragraph about the inflammation at the beginning, then about each of these markers (vcam-1 and E-selectin) and at the end how dox upregulates them in the cardiovascular. Discuss the senescence markers (p21, P53, P16, and pH2AX) a​‌‍‍‍‌‍‍‌‍‌‌‍‍‍‌‍‌‌‌‍​ssociated with doxorubicin causing inflammation and senescence. I prefer to write a paragraph about the senescence at the beginning, then about each of these markers (p21, P53, P16 , H2ax) and at the end how dox upregulate them in the cardiovascular. I have attached papers and a link that may help. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084867​‌‍‍‍‌‍‍‌‍‌‌‍‍‍‌‍‌‌‌‍​/