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Understanding Diabetes Mellitus Type 2 in Relation to C.B.’s Case

Endocrine Function:
C.B. is a significantly overweight, 48-year-old woman from the Winnebago Indian tribe who had high blood sugar and cholesterol levels three years ago but did not follow up with a clinical diagnostic work-up. She had participated in the states annual health screening program and noticed that her fasting blood sugar was 141 and her cholesterol was 225. However, she felt perfectly fine at the time and could not afford any more medications. Except for a number of female infections, she has felt fine until recently. Today, she presents to the Indian Hospital general practitioner complaining that her left foot has been weak and numb for nearly three weeks and that the foot is difficult to flex. She denies any other weakness or numbness at this time. However, she reports that she has been very thirsty lately and gets up more often at night to urinate. She has attributed these symptoms to the extremely warm weather and drinking more water to keep hydrated. She has gained a total of 65 pounds since her last pregnancy 14 years ago, 15 pounds in the last 6 months alone.

Case Study Questions

In which race and ethnic groups is DM more prevalent? Based on C.B. clinical manifestations, please compile the signs and symptoms that she is exhibiting that are compatible with the Diabetes Mellitus Type 2 diagnosis.
If C.B. develop a bacterial pneumonia on her right lower lobe, how would you expect her Glycemia values to be? Explain and support your answer.
What would be the best initial therapy non-pharmacologic and pharmacologic to be recommended to C.B?

Sample Answer

 

Understanding Diabetes Mellitus Type 2 in Relation to C.B.’s Case

Diabetes Mellitus Type 2 is a chronic metabolic disorder characterized by elevated blood sugar levels due to insulin resistance and relative insulin deficiency. It is more prevalent in certain race and ethnic groups, including African Americans, Hispanic/Latinx individuals, Native Americans, and Pacific Islanders.

In C.B.’s case study, several clinical manifestations align with a potential diagnosis of Diabetes Mellitus Type 2:

1. Hyperglycemia: Elevated fasting blood sugar levels (141 mg/dL) suggest impaired glucose regulation.

2. Polyuria: Increased thirst and nocturia (waking up at night to urinate frequently) are classic symptoms of diabetes due to the kidneys excreting excess glucose through urine.

3. Peripheral Neuropathy: Weakness, numbness, and difficulty flexing the left foot indicate potential nerve damage, a common complication of uncontrolled diabetes.

4. Weight Gain: Significant weight gain, especially abdominal obesity, is a risk factor for insulin resistance and Type 2 diabetes.

In addition to these symptoms, other signs of Type 2 diabetes may include fatigue, blurred vision, slow wound healing, and recurrent infections.

Glycemia Values in the Context of Bacterial Pneumonia

If C.B. were to develop bacterial pneumonia affecting her right lower lobe, her glycemia values would likely be elevated. Infections, including pneumonia, can cause stress on the body, leading to an increase in blood sugar levels. This response is known as stress-induced hyperglycemia, where the release of stress hormones like cortisol and catecholamines can trigger insulin resistance and glucose production by the liver.

Therefore, it would be expected that C.B.’s glycemia values would be higher during the time of bacterial pneumonia due to the physiological response to the infection.

Non-Pharmacologic and Pharmacologic Therapy Recommendations for C.B.

For C.B., the best initial therapy for managing Diabetes Mellitus Type 2 includes both non-pharmacologic and pharmacologic interventions:

1. Non-Pharmacologic Therapy:

– Dietary Modifications: Implementing a balanced diet rich in whole grains, fruits, vegetables, lean proteins, and healthy fats can help regulate blood sugar levels.
– Physical Activity: Encouraging regular exercise, such as walking or other forms of aerobic activity, can improve insulin sensitivity and aid in weight management.

2. Pharmacologic Therapy:

– Oral Antidiabetic Medications: Depending on C.B.’s glycemic control and medical history, medications such as metformin may be prescribed to lower blood sugar levels.
– Monitoring: Regular monitoring of blood glucose levels and HbA1c to assess treatment effectiveness and adjust therapy as needed.

Combining lifestyle modifications with appropriate medication management can help C.B. achieve better glycemic control and reduce the risk of diabetes-related complications. Additionally, addressing factors contributing to weight gain, such as dietary habits and physical inactivity, is crucial for overall diabetes management in this case.

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